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Accumulation of oxidized biomolecules associated with degeneration of DA neurons indicates the involvement of oxidative stress mechanisms [1], and the highly oxidizable aromatic structure of DA and its metabolites are thought to contribute to these processes [2]

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Some examples include spontaneous conversions, replication errors, exposure to free radicals, etc

Gasche C, Ahmad T, Tulassay Z, Baumgart DC, Bokemeyer B, Bning C, Howaldt S, Stallmach A

Similar results were observed in healthy older adults, where a 12-week HIIT+CIT intervention led to greater reductions in BMI and android fat mass, alongside larger improvements in gait speed, compared with HIIT plus placebo